Today at Let’sTalkRX -

Catherine O’Hara — one of Hollywood’s most beloved comic actresses — has died at age 71. O’Hara was best known for a career that spanned decades and generations, with iconic roles that made her instantly recognizable to millions of viewers.

For many fans, she’ll always be the warm (and unflappable) mom from Home Alone, a standout in Christopher Guest’s ensemble comedies, and the scene-stealing Delia Deetz in Beetlejuice. More recently, she became a modern television legend as Moira Rose in Schitt’s Creek, a role that showcased her unmatched comedic instincts and earned her major awards and renewed acclaim.

In the days since her death, tributes have poured in celebrating O’Hara’s talent, her range, and her ability to make characters feel both outrageous and deeply human. She wasn’t just funny — she was specific, fearless, and effortlessly watchable.

This week, O’Hara’s cause of death was revealed, a pulmonary embolism related to rectal cancer, and it’s drawing attention to a serious health risk that many people still don’t fully understand.

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Today at Let’sTalkRX -

O’Hara’s death certificate lists a pulmonary embolism as the immediate cause of death, with rectal cancer identified as an underlying condition.

A pulmonary embolism (PE) happens when a blood clot blocks an artery in the lungs. In most cases, the clot starts elsewhere — often in the deep veins of the leg or pelvis — a condition called deep vein thrombosis (DVT). If part of that clot breaks loose, it can travel to the lungs and become life-threatening quickly.

Pulmonary embolism symptoms can include:

Cancer patients are at higher risk for clots for several reasons. Many cancers can trigger changes in the body that make blood more likely to clot. Cancer treatments — including surgery, chemotherapy, and long periods of reduced mobility — can raise that risk even further. In other words, blood clots are not a random complication in cancer care. They’re a well-known and serious danger, especially during high-risk periods like recovery from surgery or intensive treatment.

The key takeaway is awareness. Pulmonary embolism can be sudden, but it is often treatable when caught early. For patients living with cancer and the people who love them, knowing the warning signs — and taking sudden breathing symptoms seriously — can be lifesaving.